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KMID : 0928320070070010017
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Korean Journal of Health Promotion and Disease Prevention
2007 Volume.7 No. 1 p.17 ~ p.23
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The comparison analysis between measured and estimated LDL-cholesterol
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Suh Byung-Seong
Kim Dong-il
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Abstract
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Background : Low-Density lipoprotein cholesterol(LDLC) is the main marker in hyperlipidemia. However, LDLC is usually estimated by the Friedewald equation rather than directly measured. So, we assess the validity of the formula by comparing each value.
Methods: The data were collected from 38,932 persons who took the periodic health examinations done at one university hospital in 2001. We compared the measured serum LDLC concentrations with calculated values by using the several terms of triglycerides(TG) (TG/4, TG/4.5, TG/5, TG/5.5, TG/6, TG/7, and TG/8). We also compared them by using the several groups of TG and total cholesterol level.
Results: There is the highest correlation when we using the term TG/6 (r=0.938). Especially For TG levels 100-249mg/dl, TG/6 is the most closely matching term and gave the smallest mean percent errors. The greater the TG levels were, however, the more estimation errors were occurred. Above 400mg/dl of TG, the correspondency was decreased to below 44%. Using TG/6 was also adequate independently when the total cholesterol level was 200-239mg/dl.
Conclusions: Generalizing the results, It seems more valid when we use TG/6 in the formula. And total cholesterol level is another important variable using this formula. (Korean J Health Promot Dis Prev 2007 ; 7(1) :17~23)
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KEYWORD
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LDLC, Friedewald formula, Homogeneous enzymatic method, Direct assay, Screening
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